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Iron-Catalyzed Enyne Cross-Coupling Reaction

Takuji Hatakeyama, Yuya Yoshimoto, Toma Gabriel and Masaharu Nakamura*

*International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan, Email:

T. Hatakeyama, Y. Yoshimoto, T. Gabriel, M. Nakamura, Org. Lett., 2008, 10, 5341-5344.

DOI: 10.1021/ol8020226 (free Supporting Information)


Alkynyl Grignard reagents, prepared from the corresponding alkynes and methylmagnesium bromide, react with alkenyl bromides or triflates in the presence of FeCl3 as catalyst and lithium bromide as additive to give the corresponding conjugated enynes in high to excellent yields. The reaction shows wide applicability to various terminal alkynes and alkenyl electrophiles.

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ID: J54-Y2008-3580