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FeCl3-Catalyzed Propargylation-Cycloisomerization Tandem Reaction: A Facile One-Pot Synthesis of Substituted Furans

Wen-hua Ji, Ying-ming Pan, Su-yan Zhao, Zhuang-ping Zhan*

*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. of China, Email:

W.-h. Ji, Y.-m. Pan, S.-y. Zhao, Z.-p. Zhan, Synlett, 2008, 3046-3052.

DOI: 10.1055/s-0028-1087344 (free Supporting Information)

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An efficient FeCl3-catalyzed tandem propargylation-cycloisomerization reaction of propargylic alcohols or acetates with 1,3-dicarbonyl compounds leads to highly substituted furans.

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proposed reaction pathway

Key Words

furans, iron(III) chloride, propargylic acetates, propargylic alcohols, tandem reaction

ID: J60-Y2008-3700