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A Ruthenium-Catalyzed, Atom-Economical Synthesis of Nitrogen Heterocycles

Barry M. Trost*, Nuno Maulide and Robert C. Livingston

*Department of Chemistry, Stanford University, Stanford, California 94305-5080, Email: bmtroststanford.edu

B. M. Trost, N. Maulide, R. C. Livingston, J. Am. Chem. Soc., 2008, 130, 16502-16503.

DOI: 10.1021/ja807696e (free Supporting Information)


Abstract

A ruthenium catalyzed, atom-economical domino redox isomerization/cyclization of easily available, linear aminopropargyl alcohols provides added-value nitrogen heterocycles in a single catalytic step and displays a broad scope and functional group tolerance.

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Key Words

Pyrrolidines, Piperidines


ID: J48-Y2008-3780