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Synthesis of 4-Arylcoumarins via Cu-Catalyzed Hydroarylation with Arylboronic Acids

Yoshihiko Yamamoto* and Naohiro Kirai

*Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152-8552, Japan, Email:

Y. Yamamoto, N. Kirai, Org. Lett., 2008, 10, 5513-5516.

DOI: 10.1021/ol802239n (free Supporting Information)


Arylpropionic acid methyl esters having a MOM-protected hydroxy group at the ortho position underwent hydroarylation with various arylboronic acids in MeOH at ambient temperature in the presence of a catalytic amount of CuOAc, resulting in the formation of 4-arylcoumarins in high yields after the acidic workup.

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ID: J54-Y2008-3790