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The Thermal Amidation of Carboxylic Acids Revisited

Lukas J. Gooßen*, Dominik M. Ohlmann, Paul P. Lange

*Fachbereich Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße 54, 67663 Kaiserslautern, Germany, Email:

L. J. Gooßen, D. M. Ohlmann, P. P. Lange, Synthesis, 2009, 160-164.

DOI: 10.1055/s-0028-1083277


An effective protocol for a waste-minimized, environmentally benign thermal condensation of carboxylic acids with amines has been identified. Fourteen examples demonstrate the applicability of this procedure to aliphatic, aromatic and heteroaromatic carboxylic acids and primary and secondary aliphatic as well as aromatic amines. The approach leads to the corresponding amides in good yields.

see article for more examples

Key Words

amides, amines, condensation, molecular sieves, green chemistry

ID: J66-Y2009-0040