Rapid 1,4-Alkynylation of Acyclic Enones Using K[F₃BCCR]

Ferruccio Bertolini, Simon Woodward*

*School of Chemistry, The University of Nottingham, Nottingham NG7 2RD, UK, Email: simon.woodwardnottingham.ac.uk

F. Bertolini, S. Woodward, Synlett, 2009, 51-54.

DOI: 10.1055/s-0028-1087481

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Abstract

A rapid and simple conjugate alkynylation of acyclic enones using sp-hybridised potassium organotrifluoroborates in the presence of BF₃•OEt₂ is suitable for the preparation of small compound libraries.

see article for more examples

proposed mechanism

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Key Words

conjugated alkynylation, alkynylation, 1,4-additions, enones, potassium alkynyltrifluoroborates

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ID: J60-Y2009-0050