Synthesis of 1-Methylbenzimidazoles from Carbonitriles
Jonas Sluiter, Jens Christoffers*
*Institut für Reine und Angewandte Chemie, Carl von Ossietzky-Universität Oldenburg, 26111 Oldenburg, Germany, Email: jens.christoffersuni-oldenburg.de
J. Sluiter, J. Christoffers, Synlett, 2009, 63-66.
DOI: 10.1055/s-0028-1087383
Abstract
A NaH-mediated reaction of carbonitriles and N-methyl-1,2-phenylenediamine allows the formation of N-methylbenzimidazole and tolerates acid-labile acetal protective groups. Products were further converted in Suzuki, Sonogashira, Heck and Buchwald-Hartwig reactions.
see article for more examples
Key Words
benzimidazoles, heterocycles, carbonitriles, cross-coupling
ID: J60-Y2009-0070