Desulfurizing Difluorination Reaction of Benzyl Sulfides Using IF₅

Tadahito Fukuhara, Shoji Hara*

*Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan, Email: sharaeng.hokudai.ac.jp

T. Fukuhara, S. Hara, Synlett, 2009, 198-200.

DOI: 10.1055/s-0028-1087511

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Abstract

A desulfurizing difluorination reaction of benzyl sulfides having an electron-withdrawing group such as an ester, a ketone, a nitrile, or an amide in the presence of IF5 gave gem-difluoro compounds in good yield.

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Key Words

difluoroalkanes, benzylfluorides, α-fluorination, desulfurization, hypervalent iodine, oxidation, sulfides

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ID: J60-Y2009-0190