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A Method for the Selective Protection of Aromatic Amines in the Presence of Aliphatic Amines

Valérie Perron, Shaun Abbott, Nancie Moreau, Devin Lee, Christopher Penney, Boulos Zacharie*

*ProMetic BioSciences Inc., Suite 150, 500 Cartier Blvd. W., Laval, QC, H7V 5B7, Canada, Email:

V. Perron, S. Abbott, N. Moreau, D. Lee, C. Penney, B. Zacharie, Synthesis, 2009, 283-289.

DOI: 10.1055/s-0028-1083290


A simple and efficient protection procedure is general and regioselective for the preparation of mono-N-Boc, N-Cbz, N-Fmoc or N-Alloc aromatic amines in high yield without affecting aliphatic amino groups and other functionalities.

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Key Words

amines, carbamates (Boc, Fmoc, Cbz), protecting groups, protonations, regioselectivity

ID: J66-Y2009-0220