A Method for the Selective Protection of Aromatic Amines in the Presence of Aliphatic Amines
Valérie Perron, Shaun Abbott, Nancie Moreau, Devin Lee, Christopher Penney, Boulos Zacharie*
*ProMetic BioSciences Inc., Suite 150, 500 Cartier Blvd. W.,
Laval, QC, H7V 5B7, Canada, Email: b.zacharie
prometic.com
V. Perron, S. Abbott, N. Moreau, D. Lee, C. Penney, B. Zacharie, Synthesis, 2009, 283-289.
DOI: 10.1055/s-0028-1083290
Abstract
A simple and efficient protection procedure is general and regioselective for the preparation of mono-N-Boc, N-Cbz, N-Fmoc or N-Alloc aromatic amines in high yield without affecting aliphatic amino groups and other functionalities.
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Key Words
amines, carbamates (Boc, Fmoc, Cbz), protecting groups, protonations, regioselectivity
ID: J66-Y2009-0220
