Organic Chemistry Portal



Palladium(0)-Catalyzed Benzylation of H-Phosphonate Diesters: An Efficient Entry to Benzylphosphonates

Gaston Lavéna, Jacek Stawinski*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, Email:

G. Lavéna, J. Stawinski, Synlett, 2009, 225-228.

DOI: 10.1055/s-0028-1087522


An efficient method allows the synthesis of benzylphosphonate diesters via a palladium(0)-catalyzed cross-coupling reaction between benzyl halides and H-phosphonate diesters, using Pd(OAc)2 as a palladium source and Xantphos as a supporting ligand.

see article for more examples

Microwave-Assisted Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with H-Phosphonate Diesters

M. Kalek, A. Ziadi, J. Stawinski, Org. Lett., 2008, 10, 4637-4640.

Key Words

phosphonates, benzylphosphonates, palladium cross-coupling, H-phosphonates, C-phosphonates

ID: J60-Y2009-0270