Palladium(0)-Catalyzed Benzylation of H-Phosphonate Diesters: An Efficient Entry to Benzylphosphonates
Gaston Lavéna, Jacek Stawinski*
*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, Email: jsorgan.su.se
G. Lavéna, J. Stawinski, Synlett, 2009, 225-228.
An efficient method allows the synthesis of benzylphosphonate diesters via a palladium(0)-catalyzed cross-coupling reaction between benzyl halides and H-phosphonate diesters, using Pd(OAc)2 as a palladium source and Xantphos as a supporting ligand.
see article for more examples
M. Kalek, A. Ziadi, J. Stawinski, Org. Lett., 2008, 10, 4637-4640.
phosphonates, benzylphosphonates, palladium cross-coupling, H-phosphonates, C-phosphonates