Palladium-Catalyzed, One-Pot, Three-Component Synthesis of Homoallylic Amines from Aldehydes, Anisidine, and Allyl Trifluoroacetate
Robin E. Grote and Elizabeth R. Jarvo*
*Natural Sciences I 4114, Department of Chemistry, University
of California, Irvine, Irvine California 92697, Email: erjarvo
uci.edu
R. E. Grote, E. R. Jarvo, Org. Lett., 2009, 11, 485-488.
DOI: 10.1021/ol8026297
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Abstract
A palladium complex catalyzes two transformations in one pot: formation of allylsilane from allyl trifluoroacetate using hexamethyldisilane and subsequent imine allylation. A three-component reaction was developed where preformed imines were replaced with aldehydes and anisidine. Under these reaction conditions various aldehydes react smoothly to afford homoallylic amines.
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Key Words
Homoallylic Amines (C-C Coupling, Amination), Multicomponent Reactions
ID: J54-Y2009-0320
