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Highly Enantioselective Vinyl Additions of Vinylaluminum to Ketones Catalyzed by a Titanium(IV) Catalyst of (S)-BINOL

Deepak Baburao Biradar and Han-Mou Gau*

*Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan, Email:

D. B. Biradar, H.-M. Gau, Org. Lett., 2009, 11, 499-502.

DOI: 10.1021/ol801999u (free Supporting Information)


An asymmetric addition of vinyl group to ketones using vinylaluminum reagents catalyzed by in situ prepared Ti(OiPr)4 complexes of (S)-BINOL affords diversified tertiary allylic alochols. Various aromatic ketones can be converted to allylic alcohols in excellent enantioselectivities with high yields.

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Key Words

Allylic Alcohols

ID: J54-Y2009-0350