Desulfurization of Thioamides into Amides with H2O2/ZrCl4 Reagent System
Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Yeganeh Tirandaz
*Department of Chemistry, Razi University, Kermanshah 67149, Iran, Email: kbahrami2hotmail.com, mmkhodarazi.ac.ir
K. Bahrami, M. M. Khodaei, Y. Tirandaz, Synthesis, 2009, 369-371.
The hydrogen peroxide-zirconium(IV) chloride reagent system is efficient and general for the conversion of thioamides to amides in short reaction times and good chemoselectivity, and allows a simple workup that precludes the use of toxic solvents.
see article for more examples
Trimethylsilyl Chloride Promoted Selective Desulfurization of Thiocarbonyls to Carbonyls with Hydrogen Peroxide
K. Bahrami, M. M. Khodaei, M. Tajik, Synthesis, 2010, 4282-4286.
deprotection, thioamides, amides, desulfurization, hydrogen peroxide