Desulfurization of Thioamides into Amides with H₂O₂/ZrCl₄ Reagent System

Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Yeganeh Tirandaz

*Department of Chemistry, Razi University, Kermanshah 67149, Iran, Email: kbahrami2hotmail.com, mmkhodarazi.ac.ir

K. Bahrami, M. M. Khodaei, Y. Tirandaz, Synthesis, 2009, 369-371.

DOI: 10.1055/s-0028-1083314

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Abstract

The hydrogen peroxide-zirconium(IV) chloride reagent system is efficient and general for the conversion of thioamides to amides in short reaction times and good chemoselectivity, and allows a simple workup that precludes the use of toxic solvents.

see article for more examples

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Trimethylsilyl Chloride Promoted Selective Desulfurization of Thiocarbonyls to Carbonyls with Hydrogen Peroxide

K. Bahrami, M. M. Khodaei, M. Tajik, Synthesis, 2010, 4282-4286.

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Key Words

deprotection, thioamides, amides, desulfurization, hydrogen peroxide

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ID: J66-Y2009-0360