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2-Oxazol-5-ylethanones by Consecutive Three-Component Amidation-Coupling-Cycloisomerization (ACCI) Sequence

Eugen Merkul, Oliver Grotkopp, Thomas J. J. Müller*

*Institut für Organische Chemie und Makromolekulare Chemie, Lehrstuhl für Organische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany, Email:

E. Merkul, O. Grotkopp, T. J. J. Müller, Synthesis, 2009, 502-507.

DOI: 10.1055/s-0028-1083294


Substituted oxazol-5-ylethanones can be synthesized in a consecutive three-component sequence starting with amidation of propargylamine with an acid chloride followed by cross-coupling with another acid chloride. Therefore, this diversity-oriented one-pot approach to substituted oxazoles can be considered as an amidation-coupling-cycloisomerization (ACCI) sequence.

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Novel Microwave-Assisted One-Pot Synthesis of Isoxazoles by a Three-Component Coupling-Cycloaddition Sequence

B. Willy, F. Rominger, T. J. J. Müller, Synthesis, 2008, 293-303.

Key Words

C-C coupling, catalysis, cycloisomerization, oxazoles

ID: J66-Y2009-0370