Stereoselective Formation of Alkenyl Halides via Magnesium Halide Promoted Ring Opening of Bis-Activated Cyclopropenes
Yi Wang and Hon Wai Lam*
*School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom, Email: h.lamed.ac.uk
Y. Wang, H. W. Lam, J. Org. Chem., 2009, 74, 1353-1355.
DOI: 10.1021/jo802475x (free Supporting Information)
Various bis-activated cyclopropenes undergo highly stereoselective ring-opening reactions to produce multisubstituted alkenyl halides in the presence of stoichiometric magnesium halides. Trapping of the magnesium enolate intermediates in situ allows the synthesis of highly functionalized compounds.
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