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Cobalt(II) Chloride Hexahydrate-Diisopropylamine Catalyzed Mild and Chemoselective Reduction of Carboxylic Esters with Sodium Borohydride

Arun R. Jagdale, Abhimanyu S. Paraskar, Arumugam Sudalai*

*Chemical Engineering and Process Development Division, National Chemical Laboratory, Pashan Road, Pune 411 008, India, Email:

A. R. Jagdale, A. S. Paraskar, A. Sudalai, Synthesis, 2009, 660-664.

DOI: 10.1055/s-0028-1083353

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A catalytic system of cobalt(II) chloride and diisopropylamine in combination with NaBH4 showed excellent activity in the chemoselective reduction of various carboxylic esters to their corresponding alcohols in very good yields under mild conditions. Unsaturated carboxylic esters give saturated alcohols in high yields.

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Key Words

reductions (olefins, esters), amines, catalysis, esters, alcohols, sodium borohydride

ID: J66-Y2009-0530