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A Simple and Efficient Procedure for the Synthesis of Ketone Di-sec-alkyl Acetals

Fumiaki Ono, Hirotaka Takenaka, Yuko Eguchi, Masato Endo, Tsuneo Sato*

*Department of Life Science, Kurashiki University of Science and the Arts, Kurashiki 712-8505, Japan, Email:

F. Ono, H. Takenaka, Y. Eguchi, M. Endo, T. Sato, Synlett, 2009, 487-489.

DOI: 10.1055/s-0028-1087534


Ketone di-sec-alkyl acetals are obtained in very good yields by treatment of ketones with tri-sec-alkyl orthoformate and the corresponding alcohol in the presence of a catalytic amount of cerium(III) trifluoromethanesulfonate.

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Key Words

acetals, cerium(III) trifluoromethanesulfonate, ketones, Lewis acids, tri-sec-alkyl orthoformates

ID: J60-Y2009-0570