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A Modular Synthesis of Highly Substituted Imidazolium Salts

Keiichi Hirano, Slawomir Urban, Congyang Wang and Frank Glorius*

*Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany, Email: gloriusuni-muenster.de

K. Hirano, S. Urban, C. Wang, F. Glorius, Org. Lett., 2009, 11, 1019-1022.

DOI: 10.1021/ol8029609 (free Supporting Information)


Abstract

A versatile and modular one-pot method allows the preparation of differently substituted symmetrical and unsymmetrical imidazolium salts from readily available formamidines and α-halo ketones. For many substitution patterns of the imidazolium salt products, this efficient strategy compares favorably with well-known processes in terms of yield, ease of synthesis, and robustness.

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Key Words

Imidazoles


ID: J54-Y2009-0590