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One-Pot Van Leusen Synthesis of 4,5-Disubstituted Oxazoles in Ionic Liquids

Bo Wu, Jun Wen, Ji Zhang, Jing Li, Yong-Zhe Xiang, Xiao-Qi Yu*

*Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. of China, Email:

B. Wu, J. Wen, J. Zhang, J. Li, Y.-Z. Xiang, X.-Q. Yu, Synlett, 2009, 500-504.

DOI: 10.1055/s-0028-1087547 (free Supporting Information)


An improved one-pot van Leusen oxazole synthesis using tosylmethyl isocyanide (TosMIC), aliphatic halides and various aldehydes in ionic liquids allows the preparation of 4,5-disubstituted oxazoles in high yields. The recovered ionic liquids could be reused as solvent for six runs without significant loss of yields.

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Key Words

ionic liquids, van Leusen oxazole synthesis, tosyl­methyl isocyanide, halides, aldehydes, oxazoles

ID: J60-Y2009-0610