Copper/Diethyl Azodicarboxylate Mediated Regioselective Alkynylation of Unactivated Aliphatic Tertiary Methylamine with Terminal Alkyne
Xiaoliang Xu and Xiaonian Li*
*Institute of Industrial Catalysis, College of Chemical
Engineering and Materials Science, Zhejiang University of Technology, Hangzhou
310032, People's Republic of China, Email: xnli
zjut.edu.cn
X. Xu, X. Li, Org. Lett., 2009, 11, 1027-1029.
DOI: 10.1021/ol802974b
Abstract
Mediated by copper/diethyl azodicarboxylate, regioselective alkynylation of unactivated aliphatic tertiary methylamine with terminal alkyne was successfully established. The alkynylation reaction described here has the advantage of simple operation, mild reaction conditions, good to excellent yields, and no need to exclude air and moisture.
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Key Words
Propargylamines, Diethyl Azodicarboxylate
ID: J54-Y2009-0630
