Highly Enantioselective Hydrogenation of Enamides Catalyzed by Chiral Phosphoric Acids
Guilong Li and Jon C. Antilla*
*Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, Email: jantillacas.usf.edu
G. Li, J. C. Antilla, Org. Lett., 2009, 11, 1075-1078.
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A highly enantioselective hydrogenation of enamides is catalyzed by a dual chiral-achiral acid system. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, low catalyst loadings of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.
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G. Li, Y. Liang, J. C. Antilla, J. Am. Chem. Soc., 2007, 129, 5830-5831.