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Combination of Lithium Chloride and Hexafluoroisopropanol for Friedel-Crafts Reactions

Matthieu Willot, JinChun Chen, Jieping Zhu*

*Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France, Email:

M. Willot, J. Chen, J. Zhu, Synlett, 2009, 577-580.

DOI: 10.1055/s-0028-1087566

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A combination of weak Lewis acid (LiCl) and weak Brønsted acid (hexafluoroisopropanol, HFIP) promotes efficiently the Friedel-Crafts reaction of electron-rich aromatic compounds with ethyl glyoxylate.

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Key Words

Friedel-Crafts reaction, glyoxylate, lithium chloride, hexafluoroisopropanol, Lewis acid, Brønsted acid, arylation, α-hydroxy esters

ID: J60-Y2009-0710