Micellar-System-Mediated Direct Fluorination of Ketones in Water
Gaj Stavber, Marko Zupan, Stojan Stavber*
*Laboratory of Organic and Bioorganic Chemistry, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia, Email: stojan.stavberijs.si
G. Stavber, M. Zupan, S. Stavber, Synlett, 2009, 589-594.
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A micellar system was developed and applied for direct regioselective fluorination of various cyclic and acyclic ketones to α-fluoroketones in water as reaction medium with Selectfluor (F-TEDA-BF4) as fluorinating reagent. The inexpensive ionic amphiphile sodium dodecyl sulfate (SDS) was found to be an excellent promoter.
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S. Stavber, M. Jereb, M. Zupan, Synthesis, 2002, 2609-2615.