Organic Chemistry Portal



Micellar-System-Mediated Direct Fluorination of Ketones in Water

Gaj Stavber, Marko Zupan, Stojan Stavber*

*Laboratory of Organic and Bioorganic Chemistry, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia, Email:

G. Stavber, M. Zupan, S. Stavber, Synlett, 2009, 589-594.

DOI: 10.1055/s-0028-1087924

see article for more reactions


A micellar system was developed and applied for direct regioselective fluorination of various cyclic and acyclic ketones to α-fluoroketones in water as reaction medium with Selectfluor (F-TEDA-BF4) as fluorinating reagent. The inexpensive ionic amphiphile sodium dodecyl sulfate (SDS) was found to be an excellent promoter.

see article for more examples

Direct α-Fluorination of Ketones Using N-F Reagents

S. Stavber, M. Jereb, M. Zupan, Synthesis, 2002, 2609-2615.

Key Words

ketones, fluorination, micelles, selectfluor, water

ID: J60-Y2009-0730