Micellar-System-Mediated Direct Fluorination of Ketones in Water
Gaj Stavber, Marko Zupan, Stojan Stavber*
*Laboratory of Organic and Bioorganic Chemistry, Jožef Stefan
Institute, Jamova 39, 1000 Ljubljana, Slovenia, Email: stojan.stavber
ijs.si
G. Stavber, M. Zupan, S. Stavber, Synlett, 2009, 589-594.
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Abstract
A micellar system was developed and applied for direct regioselective fluorination of various cyclic and acyclic ketones to α-fluoroketones in water as reaction medium with Selectfluor (F-TEDA-BF4) as fluorinating reagent. The inexpensive ionic amphiphile sodium dodecyl sulfate (SDS) was found to be an excellent promoter.
see article for more examples
Direct α-Fluorination of Ketones Using N-F Reagents
S. Stavber, M. Jereb, M. Zupan, Synthesis, 2002, 2609-2615.
Key Words
ketones, fluorination, micelles, selectfluor, water
ID: J60-Y2009-0730
