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Efficient Boron-Copper Additions to Aryl-Substituted Alkenes Promoted by NHC-Based Catalysts. Enantioselective Cu-Catalyzed Hydroboration Reactions

Yunmi Lee and Amir H. Hoveyda*

*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, Email:

Y. Lee, A. H. Hoveyda, J. Am. Chem. Soc., 2008, 131, 3160-3161.

DOI: 10.1021/ja809382c

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Efficient and site selective boron-copper addition processes involving acyclic and cyclic disubstituted aryl olefins are promoted with a readily available N-heterocyclic carbene (NHC) complex. In situ protonation of the C-Cu bond in the presence of MeOH leads to efficient catalyst turnover, constituting a net Cu-catalyzed hydroboration process.

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ID: J48-Y2009-0740