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Highly Functional Group Tolerance in Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles under Mild Conditions

Liangbo Zhu, Gaocan Li, Liang Luo, Peng Guo, Jingbo Lan and Jingsong You*

*Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, People's Republic of China, Email:

L. Zhu, G. Li, L. Luo, P. Guo, J. Lan, J. You, J. Org. Chem., 2009, 74, 2200-2202.

DOI: 10.1021/jo802669b


A copper-catalyzed N-arylation reaction of imidazole proceeds under very mild conditions in the absence of additional ligand. This protocol tolerates an array of thermally sensitive functional groups, but also achieves high chemoselectivity.

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Key Words

imidazoles, Ullman reaction, N-arylation

ID: J42-Y2009-0810