An Improved Bouveault-Blanc Ester Reduction with Stabilized Alkali Metals
Brian S. Bodnar* and Paul F. Vogt
*Process Development Services, SiGNa Chemistry, Inc., 1 Deer Park Drive, Suite C, Monmouth Junction, New Jersey 08852, Email: bsbodnarsignachem.com
B. S. Bodnar, P. F. Vogt, J. Org. Chem., 2009, 74, 2598-2600.
DOI: 10.1021/jo802778z (free Supporting Information)
Sodium in silica gel (Na-SG) - a safe, free-flowing powder - has been used for the Bouveault-Blanc reduction of various aliphatic esters. Primary alcohols were prepared in excellent yield under mild reaction conditions.
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