Solid-State Synthesis of β-Enamino Ketones from Solid 1,3-Dicarbonyl Compounds and Ammonium Salts or Amines

Shi-Liang Xu, Cheng-Ping Li, Jing-Hua Li*

*College of Pharmacuetical Sciences, Zhejiang University of Technology, 310032 Hangzhou, P. R. of China, Email: lijhzjut.edu.cn

S.-L. Xu, C.-P. Li, J.-H. Li, Synlett, 2009, 818-822.

DOI: 10.1055/s-0028-1087914

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Abstract

Mechanochemical grinding in the presence of KHSO₄ and SiO₂ enables a facile amination of solid 1,3-dicarbonyl compounds with ammonium salts or amines in solid state to yield the corresponding β-imino derivatives in high yields. The method has the advantage of simple manipulation and mild conditions.

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Key Words

enamination, 1,3-dicarbonyl compounds, solid state, mechanochemistry

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ID: J60-Y2009-0940