Organic Chemistry Portal



Acyl Transfer Catalysis with 1,2,4-Triazole Anion

Xing Yang and Vladimir B. Birman*

*Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, Email:

X. Yang, V. B. Birman, Org. Lett., 2009, 11, 1499-1502.

DOI: 10.1021/ol900098q

see article for more examples


Deprotonated 1,2,4-triazole is an active acyl transfer catalyst suitable for the aminolysis and transesterification of esters.

see article for more reactions

see article for more examples

proposed mechanism

Key Words

Acetamides, Amides, Organocatalysis

ID: J54-Y2009-0990