Efficient Three-Component Strecker Reaction of Aldehydes/Ketones via NHC-Amidate Palladium(II) Complex Catalysis
Jamie Jarusiewicz, Yvonne Choe, Kyung Soo Yoo, Chan Pil Park and Kyung Woon Jung*
*Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-0166, Email: kwjungusc.edu
J. Jarusiewicz, Y. Choe, K. Soo. Yoo, C. P. Park, K. W. Jung, J. Org. Chem., 2009, 74, 2873-2876.
DOI: 10.1021/jo900163w (free Supporting Information)
A simple and efficient one-pot, three-component Strecker reaction of aldehydes and ketones with aliphatic or aromatic amines and trimethylsilyl cyanide in the presence of a palladium Lewis acid catalyst allows the synthesis of α-aminonitriles in good yields at room temperature.
see article for more examples