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One-Pot Synthesis of Imines and Secondary Amines by Pd-Catalyzed Coupling of Benzyl Alcohols and Primary Amines

Min Serk Kwon, Sungjin Kim, Sungho Park, William Bosco, Ravi Kumar Chidrala and Jaiwook Park*

*Department of Chemistry, Pohang University of Science and Technology (POSTECH), San 31 Hyojadong, Pohang, Kyeongbuk 790-784, Republic of Korea, Email:

M. S. Kwon, S. Kim, S. Park, W. Bosco, R. K. Chidrala, J. Park, J. Org. Chem., 2009, 74, 2877-2879.

DOI: 10.1021/jo8026609


Imines and secondary amines were synthesized selectively by a Pd-catalyzed one-pot reaction of benzyl alcohols with primary amines. The reactions did not require any additives and were effective for a wide range of alcohols and amines.

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Key Words

Imines, Benzyl Amines, Oxygen, Hydrogen

ID: J42-Y2009-1100