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Synthesis of Isoquinoline Derivatives via Ag-Catalyzed Cyclization of 2-Alkynyl Benzyl Azides

Yan-Ning Niu, Ze-Yi Yan, Guo-Lin Gao, Hong-Li Wang, Xing-Zhong Shu, Ke-Gong Ji and Yong-Min Liang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China, Email: liangymlzu.edu.cn

Y.-N. Niu, Z.-Y. Yan, G.-L. Gao, H.-L. Wang, X.-Z. Shu, K-G. Ji, Y.-M. Liang, J. Org. Chem., 2009, 74, 2893-2896.

DOI: 10.1021/jo900010m (free Supporting Information)


Abstract

Ag-catalyzed cyclization of 2-alkynyl benzyl azides offers an efficient method for the synthesis of substituted isoquinolines. The reaction proceeds smoothly in good yields and tolerates various functional groups.

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Key Words

Isoquinolines


ID: J42-Y2009-1160