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A Novel Approach to the Synthesis of Highly Functionalized Pyrroles

Mohammad Anary-Abbasinejad*, Khadije Charkhati, Hossein Anaraki-Ardakani

*Department of Chemistry, Islamic Azad University, Yazd Branch, P. O. Box 89195-155, Yazd, Iran, Email:

M. Anary-Abbasinejad, K. Charkhati, H. Anaraki-Ardakani, Synlett, 2009, 1115-1117.

DOI: 10.1055/s-0028-1088224


A new and efficient three-component reaction between dialkyl acetylenedicarboxylates, aromatic amines, triphenylphosphine, and arylglyoxals afforded polysubstituted pyrrole derivatives in high yields. The reactions were performed in dichloromethane at room temperature and under neutral conditions.

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proposed reaction pathway

Efficient Synthesis of Functionalized 2,5-Dihydropyrrole Derivatives by Ph3P-Promoted Condensation between Acetylene Esters and α-Arylamino Ketones

M. Anary-Abbasinejad, E. Poorhassan, A. Hassanabadi, Synlett, 2009, 1929-1932.

Key Words

pyrrole derivatives, dialkyl acetylenedicarboxylates, triphenylphosphine, multicomponent reactions, Wittig reaction

ID: J60-Y2009-1190