A Novel Approach to the Synthesis of Highly Functionalized Pyrroles
Mohammad Anary-Abbasinejad*, Khadije Charkhati, Hossein Anaraki-Ardakani
*Department of Chemistry, Islamic Azad University, Yazd Branch, P. O. Box 89195-155, Yazd, Iran, Email: mohammadanaryyahoo.com
M. Anary-Abbasinejad, K. Charkhati, H. Anaraki-Ardakani, Synlett, 2009, 1115-1117.
A new and efficient three-component reaction between dialkyl acetylenedicarboxylates, aromatic amines, triphenylphosphine, and arylglyoxals afforded polysubstituted pyrrole derivatives in high yields. The reactions were performed in dichloromethane at room temperature and under neutral conditions.
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proposed reaction pathway
M. Anary-Abbasinejad, E. Poorhassan, A. Hassanabadi, Synlett, 2009, 1929-1932.