A Novel Approach to the Synthesis of Highly Functionalized Pyrroles
Mohammad Anary-Abbasinejad*, Khadije Charkhati, Hossein Anaraki-Ardakani
*Department of Chemistry, Islamic Azad University, Yazd
Branch, P. O. Box 89195-155, Yazd, Iran, Email: mohammadanaryyahoo.com
M. Anary-Abbasinejad, K. Charkhati, H. Anaraki-Ardakani, Synlett, 2009, 1115-1117.
Abstract
A new and efficient three-component reaction between dialkyl acetylenedicarboxylates, aromatic amines, triphenylphosphine, and arylglyoxals afforded polysubstituted pyrrole derivatives in high yields. The reactions were performed in dichloromethane at room temperature and under neutral conditions.
see article for more examples
proposed reaction pathway
M. Anary-Abbasinejad, E. Poorhassan, A. Hassanabadi, Synlett, 2009, 1929-1932.
Key Words
pyrrole derivatives, dialkyl acetylenedicarboxylates, triphenylphosphine, multicomponent reactions, Wittig reaction
ID: J60-Y2009-1190