Organic Chemistry Portal



A Broadly Applicable Mild Method for the Synthesis of gem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes

Yun Li, Hong-Dong Hao, Qi Zhang and Yikang Wu*

*State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email:

Y. Li, H.-D. Hao, Q. Zhang, Y. Wu, Org. Lett., 2009, 11, 1615-1618.

DOI: 10.1021/ol900262t


Ketones or ketals were readily converted into the corresponding gem-dihydroperoxides in high yields by treatment with ethereal H2O2 at ambient temperature in the presence of phosphomolybdic acid (PMA) as catalyst.

see article for more examples

see article for more reactions

Perhydrolysis in Ethereal H2O2 Mediated by MoO2(acac)2: Distinct Chemoselectivity between Ketones, Ketals, and Epoxides

X. An, Q. Zha, Y. Wu, Org. Lett., 2019, 21, 1542-1546.

Facile Ring-Opening of Oxiranes by H2O2 Catalyzed by Phosphomolybdic Acid

Y. Li, H.-D. Hao, Y. Wu, Org. Lett., 2009, 11, 2691-2694.

Key Words

gem-diperoxides, peroxides, hydrogen peroxide

ID: J54-Y2009-1200