A Broadly Applicable Mild Method for the Synthesis of gem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes

Yun Li, Hong-Dong Hao, Qi Zhang and Yikang Wu*

*State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email: yikangwumail.sioc.ac.cn

Y. Li, H.-D. Hao, Q. Zhang, Y. Wu, Org. Lett., 2009, 11, 1615-1618.

DOI: 10.1021/ol900262t

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Abstract

Ketones or ketals were readily converted into the corresponding gem-dihydroperoxides in high yields by treatment with ethereal H₂O₂ at ambient temperature in the presence of phosphomolybdic acid (PMA) as catalyst.

see article for more examples

see article for more reactions

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Perhydrolysis in Ethereal H₂O₂ Mediated by MoO₂(acac)₂: Distinct Chemoselectivity between Ketones, Ketals, and Epoxides

X. An, Q. Zha, Y. Wu, Org. Lett., 2019, 21, 1542-1546.

Facile Ring-Opening of Oxiranes by H₂O₂ Catalyzed by Phosphomolybdic Acid

Y. Li, H.-D. Hao, Y. Wu, Org. Lett., 2009, 11, 2691-2694.

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Key Words

gem-diperoxides, peroxides, hydrogen peroxide

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ID: J54-Y2009-1200