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Zirconium-Catalyzed Intermolecular Hydroamination of Unactivated Olefins

Lei Yang, Li-Wen Xu*, Wei Zhou, Yue-Hua Gao, Wei Sun, Chun-Gu Xia*

*State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China, Email:,

L. Yang, L.-W. Xu, W. Zhou, Y.-H. Gao, W. Sun, C.-G. Xia, Synlett, 2009, 1167-1171.

DOI: 10.1055/s-0028-1088151

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A highly efficient hydroamination of sulfonamides, carboxamides, and carbamates with unactivated olefins is catalyzed by an inexpensive zirconium salt under mild reaction conditions. The reactions gave good to excellent yields of the Markovnikov products.

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Key Words

hydroamination, olefins, amides, sulfonamides, carbamates, zirconium salts

ID: J60-Y2009-1250