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Brønsted Acid-Catalyzed Propargylation/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides

Ying-ming Pan, Fei-jian Zheng, Hai-xin Lin and Zhuang-ping Zhan*

*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People’s Republic of China, Email: zpzhanxmu.edu.cn

Y.-M. Pan, F.-J. Zheng, H.-X. Lin, Z.-P. Zhan, J. Org. Chem., 2009, 74, 3148-3151.

DOI: 10.1021/jo8027533 (free Supporting Information)


Abstract

An efficient one-pot propargylation/cycloisomerization tandem process provides a rapid and efficient access to substituted oxazoles from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst.

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Key Words

Oxazoles


ID: J42-Y2009-1260