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Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

Mark R. Biscoe and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, Email:

M. R. Biscoe, S. L. Buchwald, Org. Lett., 2009, 11, 1773-1775.

DOI: 10.1021/ol900295u (free Supporting Information)


An efficient monoarylation of acetate esters and aryl methyl ketones with aryl chlorides is easily accomplished under mild conditions, that tolerate a wide array of heterocyclic substrates, using recently reported palladium precatalysts.

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ID: J54-Y2009-1280