Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides
Mark R. Biscoe and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, Email: sbuchwalmit.edu
M. R. Biscoe, S. L. Buchwald, Org. Lett., 2009, 11, 1773-1775.
DOI: 10.1021/ol900295u
Abstract
An efficient monoarylation of acetate esters and aryl methyl ketones with aryl chlorides is easily accomplished under mild conditions, that tolerate a wide array of heterocyclic substrates, using recently reported palladium precatalysts.
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ID: J54-Y2009-1280