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A Facile Mild Deprotection Protocol for 1,3-Dithianes and 1,3-Dithiolanes with 30% Hydrogen Peroxide and Iodine Catalyst in Aqueous Micellar System

Nemai C. Ganguly*, Sujoy Kumar Barik

*Department of Chemistry, University of Kalyani, Kalyani 741235, WB, India, Email:

N. G. Ganguly, S. K. Barik, Synthesis, 2009, 1393-1399.

DOI: 10.1055/s-0028-1088023


A simple protocol for the deprotection of 1,3-dithianes and 1,3-dithiolanes showed tolerance for a number of phenol and amino protecting groups using 30% aqueous hydrogen peroxide activated by iodine catalyst (5 mol%) in water in the presence of sodium dodecyl sulfate (SDS) under essentially neutral conditions without any detectable overoxidation.

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Key Words

1,3-dithianes, 1,3-dithiolanes, iodine, 30% hydrogen peroxide, sodium dodecyl sulfate (SDS)

ID: J66-Y2009-1300