Rh(I)-Catalyzed CO Gas-Free Carbonylative Cyclization Reactions of Alkynes with 2-Bromophenylboronic Acids Using Formaldehyde
Tsumoru Morimoto*, Kae Yamasaki, Akihisa Hirano, Ken Tsutsumi, Natsuko Kagawa, Kiyomi Kakiuchi, Yasuyuki Harada, Yoshiya Fukumoto, Naoto Chatani and Takanori Nishioka
*Graduate School of Materials Science, Nara Institute of
Science and Technology (NAIST), Takayama, Ikoma, Nara 630-0192, Japan, Email:
morimoto
ms.naist.jp
T. Morimoto, K. Yamasaki, A. Hirano, K. Tsutusmi, N. Kagawa, K. Kakiuchi, Y. Harada, Y. Fukukomoto, N. Chatani, T. Nishioka, Org. Lett., 2009, 11, 1777-1780.
DOI: 10.1021/ol900327x
Abstract
In the presence of a rhodium catalyst, paraformaldehyde enables a CO gas-free carbonylative cyclization of alkynes with 2-bromophenylboronic acids to yield indenone derivatives. Rhodium-catalyzed decarbonylation of formaldehyde is followed by carbonylation of alkynes with 2-haloboronic acids, respectively, leading to efficient whole carbonylation.
see article for more examples
Key Words
Indenones, Multicomponent Reactions
ID: J54-Y2009-1320
