Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation
Elena Riva, Stefania Gagliardi, Caterina Mazzoni, Daniele Passarella, Anna Rencurosi, Daniele Vigo and Marisa Martinelli*
*NiKem Research Srl, Via Zambeletti 25, 20021 Baranzate, Milan, Italy, Email: marisa.martinellinikemresearch.com
E. Riva, S. Gagliardi, C. Mazzoni, D. Passarella, A. Rencurosi, D. Vigo, M. Martinelli, J. Org. Chem., 2009, 74, 3540-3543.
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for increased reaction rate and higher product purity.
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