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Synthesis of Aromatic Esters via Pd-Catalyzed Decarboxylative Coupling of Potassium Oxalate Monoesters with Aryl Bromides and Chlorides

Rui Shang, Yao Fu*, Jia-Bin Li, Song-Lin Zhang, Qing-Xiang Guo and Lei Liu

*Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, Email: fuyaoustc.edu.cn

R. Shang, Y. Fu, J.-B. Li, S.-L. Zhang, Q.-X. Guo, L. Liu, J. Am. Chem. Soc., 2009, 131, 5738-5739.

DOI: 10.1021/ja900984x (free Supporting Information)


Abstract

Pd-catalyzed decarboxylative cross-coupling of aryl iodides, bromides, and chlorides with potassium oxalate monoesters is potentially useful for laboratory-scale synthesis of aryl and alkenyl esters. Bulky, electron-rich bidentate phosphine ligands are preferred in the reaction, whereas Cu is not needed for decarboxylation.

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Key Words

Aromatic Esters


ID: J48-Y2009-1400