Copper-Catalyzed Domino Rearrangement/Dehydrogenation Oxidation/Carbene Oxidation for One-Pot Regiospecific Synthesis of Highly Functionalized Polysubstituted Furans
Hua Cao, Huanfeng Jiang*, Wenjuan Yao and Xiaohang Liu
*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: jianghfscut.edu.cn
H. Cao, H. Jiang, W. Yao, X. Liu, Org. Lett., 2009, 11, 1931-1933.
DOI: 10.1021/ol900364y (free Supporting Information)
A mild and efficient domino reaction allows a regiospecific synthesis of polysubstituted furans in moderate yields via a copper(I)-catalyzed rearrangement/dehydrogenation oxidation/carbene oxidation sequence of 1,5-enynes in situ formed from alkynols and diethyl but-2-ynedioate.
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W. Liu, H. Jiang, M. Zhang, C. Qi, J. Org. Chem., 2010, 75, 966-968.