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Two Titanium-Catalyzed Reaction Sequences for Syntheses of Pyrroles from (E/Z)-Chloroenynes or α-Haloalkynols

Lutz Ackermann*, René Sandmann and Ludwig T. Kaspar

*Institut für Organische and Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany, Email:

L. Ackermann, R. Sandmann, L. T. Kaspar, Org. Lett., 2009, 11, 2031-2034.

DOI: 10.1021/ol900522g (free Supporting Information)


Titanium-catalyzed intermolecular hydroaminations enabled efficient, user-friendly one-pot reactions for the preparations of 2-substituted and fully substituted pyrroles from (E/Z)-chloroenynes and easily accessible α-haloalkynols, respectively.

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ID: J54-Y2009-1420