Transition-Metal-Free Carboxylation of Organozinc Reagents Using CO₂ in DMF Solvent

Koji Kobayashi and Yoshinori Kondo*

*Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki-aza aoba 6-3, Aoba-ku, Sendai 980-8578, Japan, Email: ykondomail.pharm.tohoku.ac.jp

K. Kobayashi, Y. Kondo, Org. Lett., 2009, 11, 2035-2037.

DOI: 10.1021/ol900528h

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Abstract

The presence of LiCl enabled an efficient process for the carboxylation of functionalized organozinc reagents with CO₂ in DMF as solvent.

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Key Words

Carboxylation (Arenes, Alkanes, Alkenes)

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ID: J54-Y2009-1440