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One-Pot Synthesis of N-Arylpyrazoles from Arylhalides

Brian S. Gerstenberger*, Mark R. Rauckhorst and Jeremy T. Starr

*Pfizer Global Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, Email: brian.gerstenbergerpfizer.com

B. S. Gerstenberger, M. R. Rauckhorst, J. T. Starr, Org. Lett., 2009, 11, 2097-2100.

DOI: 10.1021/ol900515a (free Supporting Information)


Abstract

A simple one-pot method allows the synthesis of diversely functionalized N-arylpyrazoles from aryl nucleophiles, di-tert-butylazodicarboxlate, and 1,3-dicarbonyl or equivalent compounds.

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Key Words

Pyrazoles


ID: J54-Y2009-1470