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Synthesis of Novel Chiral Phase-Transfer Catalysts and Their Application to Asymmetric Synthesis of α-Amino Acid Derivatives

Wei He, Quanjun Wang, Qiaofeng Wang, Bangle Zhang, Xiaoli Sun, Shengyong Zhang*

*Department of Chemistry, School of Pharmacy, The Fourth Military Medical University, 17 West Changle Road, 710032, Xi'an Shaanxi Province, P. R. of China, Email:

W. He, Q. Wang, Q. Wang, B. Zhang, X. Sun, S. Zhang, Synlett, 2009, 1311-1314.

DOI: 10.1055/s-0029-1216736


Using a cinchonine-derived alkaloid catalyst, enantioselective alkylations of N-(diphenylmethylene) glycine tert-butyl ester were efficiently carried out with various alkyl halides to give products in high enantiomeric excess.

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Key Words

asymmetric catalysis, alkylation, O'Donnell Amino Acid Synthesis, phase-transfer catalysis, organocatalysis, cinchona alkaloids

ID: J60-Y2009-1570