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Metal-Brønsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

Chaoqun Li, Barbara Villa-Marcos and Jianliang Xiao*

*Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K., Email:

C. Li, B. Villa-Marcos, J. Xiao, J. Am. Chem. Soc., 2009, 131, 6967-6969.

DOI: 10.1021/ja9021683


Cooperative catalysis of an Ir(III)-diamine complex and a chiral phosphoric acid or its conjugate base enables a direct reductive amination of a wide range of ketones.

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Key Words

reductive amination, aryl amines, hydrogen

ID: J48-Y2009-1590