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Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

Chong Han and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

C. Han, S. L. Buchwald, J. Am. Chem. Soc., 2009, 131, 7532-7533.

DOI: 10.1021/ja902046m


A palladium catalyst composed of a biaryldialkylphosphine ligand effectively promotes the Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool.

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Key Words

Negishi Coupling, Arenes

ID: J48-Y2009-1720