Synthetic Method for the Preparation of 2-Aminomethyl-1,3-diene Derivatives through Indium-Mediated 1,3-Butadien-2-ylation of Imines
Dong Seomoon, Jaemyung A and Phil Ho Lee*
*National Research Laboratory for Catalytic Organic Reaction, Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea, Email: phleekangwon.ac.kr
D. Seomoon, J. A, P. H. Lee, Org. Lett., 2009, 11, 2401-2404.
DOI: 10.1021/ol9005213 (free Supporting Information)
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An efficient method for the preparation of various 2-aminomethyl-1,3-dienes was developed through the reaction of imines with an organoindium reagent generated in situ from indium and 1,3-dibromo-2-butyne. Three-component reactions of aldehydes, amines, and organoindium reagents gave successful results in a one-pot process.
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