Reaction between N-Isocyaniminotriphenylphosphorane, Aldehydes, and Carboxylic Acids: A One-Pot and Three-Component Synthesis of 2-Aryl-5-hydroxyalkyl-1,3,4-oxadiazoles
Mehdi Adib*, Mahdi Riazati Kesheh, Samira Ansari, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran, Email: madibkhayam.ut.ac.ir
M. Adib, M. R. Kesheh, S. Ansari, H. R. Bijanzadeh, Synlett, 2009, 1575-1578.
DOI: 10.1055/s-0029-1217337 (free Supporting Information)
N-Isocyaniminotriphenylphosphorane, aldehydes, and benzoic acids undergo a one-pot, three-component reaction under mild conditions to afford 2-aryl-5-hydroxyalkyl-1,3,4-oxadiazoles in good yields.
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1,3,4-oxadiazoles, 2-aryl-5-hydroxyalkyl-1,3,4-oxadiazoles, N-isocyaniminotriphenylphosphorane, aldehydes, carboxylic acids, three-component reactions, multicomponent reactions, cyclizations, heterocycles