Reaction between N-Isocyaniminotriphenylphosphorane, Aldehydes, and Carboxylic Acids: A One-Pot and Three-Component Synthesis of 2-Aryl-5-hydroxyalkyl-1,3,4-oxadiazoles
Mehdi Adib*, Mahdi Riazati Kesheh, Samira Ansari, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science,
University of Tehran, PO Box 14155-6455, Tehran, Iran, Email: madib
khayam.ut.ac.ir
M. Adib, M. R. Kesheh, S. Ansari, H. R. Bijanzadeh, Synlett, 2009, 1575-1578.
DOI: 10.1055/s-0029-1217337
Abstract
N-Isocyaniminotriphenylphosphorane, aldehydes, and benzoic acids undergo a one-pot, three-component reaction under mild conditions to afford 2-aryl-5-hydroxyalkyl-1,3,4-oxadiazoles in good yields.
see article for more examples
proposed mechanism
Key Words
1,3,4-oxadiazoles, 2-aryl-5-hydroxyalkyl-1,3,4-oxadiazoles, N-isocyaniminotriphenylphosphorane, aldehydes, carboxylic acids, three-component reactions, multicomponent reactions, cyclizations, heterocycles
ID: J60-Y2009-1760
