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A General and Convenient Catalytic Synthesis of Nitriles from Amides and Silanes

Shaolin Zhou, Kathrin Junge, Daniele Addis, Shoubhik Das and Matthias Beller*

*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany, Email:

S. Zhou, K. Junge, D. Addis, S. Das, M. Beller, Org. Lett., 2009, 11, 2461-2464.

DOI: 10.1021/ol900716q


A convenient protocol for the catalytic dehydration of aromatic and aliphatic amides using silanes in the presence of catalytic amounts of fluoride allows the synthesis of a wide range of aliphatic and aromatic nitriles with high selectivity under mild conditions.

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Key Words

Nitriles, Phenylsilane

ID: J54-Y2009-1800